Paul M Heerdt

Professor

Research Departments & Organizations

Yale University: Yale School of Medicine: Faculty Research

Research Interests

Analytical, Diagnostic and Therapeutic Techniques and Equipment; Cardiovascular Diseases; Chemicals and Drugs; Heart Diseases

Research Summary

Over the past 25+ years, the vast majority of my research has been within 3 broad categories: a) cardiopulmonary adaptation to the stresses of anesthesia and surgery; b) evaluation of hemodynamic monitoring devices; and c) development of novel neuromuscular blocking drugs. Studies involving cardiopulmonary physiology have been conducted in both the laboratory and clinic, with an emphasis upon a systems biology approach that incorporates functional and molecular aspects of adaptation. Most recently, my laboratory has been incorporating aging and working with analytic approaches for quantifying the efficiency of mechanical coupling between the heart and circulation during acute and chronic pulmonary hypertension. Device evaluations have been largely focused upon methods for monitoring blood flow and tissue perfusion; recent studies have involved experimental models of shock. Our drug development program also involves both laboratory and clinical work, with investigation focused on a novel class of drugs that undergo “molecular inactivation” by the amino acid cysteine. This research has resulted in the design and synthesis of a series of molecules, one of which was recently evaluated for safety and efficacy in a clinical trial.

Research funding and salary support have been provided by multiple foundations, industry sponsors, the Society of Cardiovascular Anesthesiologists, the American Heart Association, and the National Institutes of Health.

Clinical Trials

Conditions Study Title
Diseases of the Cardiovascular System Safety and Efficacy of Preoperative Antithrombin Supplementation in Patients Undergoing High-Risk Cardiopulmonary Bypass

Selected Publications

See list of PubMed publications

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Contact Info

Paul M Heerdt