Research Departments & Organizations
Research related to Neuro Anesthesia, cerebral physiology, cerebral blood flow (CBF) regulation, tissue oxygenation monitoring and management, outcome improvement.
Extensive Research Description
Dr. Meng’s clinical research has been focusing on the following aspects.
Improving patient outcome via optimization of organ perfusion and tissue oxygenation. Organ ischemia & tissue hypoxia is one of the root causes of certain perioperative morbidities. Timely detection and correction of these mishaps contribute to an improved outcome. The first step of this query is the capacity to reliably monitor organ perfusion and tissue oxygenation. The advent of tissue oximetry based on near-infrared spectroscopy (NIRS) enables the clinician to monitor the balance between tissue oxygen consumption and supply continuously and non-invasively at the patient’s bedside. Research has been done to understand how the perioperative factors/interventions affect cerebral oxygenation monitored using NIRS. Investigation has also been done to understand how intraoperative tissue oxygenation of different tissue beds, e.g. cerebral tissue vs. muscular tissue, is associated with postoperative outcomes. Yet, the fundamental step of this query is to test if tissue oxygenation – guided care improves the outcomes that matter most to patients. Even though outcome research has been done previously, various methodological limitations exist. The future research should address the definition of an individual patient’s baseline value that is associated with a beneficial outcome, the threshold for intervention, and the patient populations that benefit from tissue oxygenation – guided care.
Improving patient outcome via choosing the appropriate anesthetic technique. The aspects of anesthetic technique include, but not limited to, monitored anesthesia care vs. general anesthesia, laryngeal mask airway vs. endotracheal tube, volatile vs. intravenous agents, the strategies of hemodynamic management, and the modes and settings of mechanical ventilation, etc. The available evidence has suggested an association between a specific aspect of anesthetic technique and patient outcome. However, due to the multiplicity of the aspects of the anesthetic technique and the complexity of randomized controlled trial in clinical setting, much work is needed to better understand the effect of different anesthetic management on patient outcome.
Yale New Haven Hospital New Haven, United States (2016)